Location, Location, Location: EphB4:Ephrin-B2 Signaling Depends on Its Spatial Arrangement
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چکیده
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Synapse Location during Growth Depends on Glia Location
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D etermining how cells distinguish between adaptive and maladaptive signals when they appear to share the same molecular pathways has been a vexing biological problem. The ability to identify distinctive features of a pathophysiological response compared with a physiological response would allow for the rational design of approaches to eliminate or diminish undesirable consequences of pathophys...
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Intra-abdominal fat is an established risk factor for the metabolic syndrome. In this issue of Cell Metabolism, Tran et al. (2008) test the cell-autonomous and location-related properties of transplanted intra-abdominal and subcutaneous fat depots. While subcutaneous fat seems to confer metabolic benefits, species differences in adipose biology justify caution in interpreting the results.
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Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin αE, ITGAE) abundantly infiltrate HGSCs, strongly correl...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2018
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2018.07.014